Tomographic Comparison of Aerosol Lung Distribution With Two Nebulizers Through a High Flow Nasal Cannula

Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Status: Completed

Conditions: Healthy

Treatments: Drug: Technetium-99m - Diethylenetriaminepentaacetic acid; Device: Jet Nebulizer; Other: Single photon emission computed tomography; Other: Spirometry; Device: Aeroneb Solo

Study type: Interventional

Funder types: Other

Identifiers

NCT02429817

Aerospect-02

Details and patient eligibility

About

Vibrating-mesh nebulizers ensure currently the best deposition output and are recommended in routine use in intensive care unit. However, jet nebulizers remain the most frequently used nebulizers.

On a bench study, aerosol delivery through a high flow nasal cannula (HFNC) was increased using a vibrating-mesh nebulizer as compared to a jet nebulizer.

Lung distribution of nebulized particles delivered through a HFNC has never been investigated in vivo. The aim of this study was to compare aerosol lung distribution with both nebulizers through a HFNC by SPECT-CT.

Enrollment: 6 patients

Sex: Male

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy respiratory function

Exclusion criteria

• Pulmonary disease

Trial design

6 participants in 2 patient groups

Aeroneb Solo

Active Comparator group

Description:

Subjects inhaled radiolabelled aerosol via the Aeroneb Solo connected to the high flow nasal cannula.

Treatment:

Drug: Technetium-99m - Diethylenetriaminepentaacetic acid

Device: Aeroneb Solo

Other: Single photon emission computed tomography

Other: Spirometry

Standard Jet Nebulizer

Active Comparator group

Description:

Subjects inhaled radiolabelled aerosol via the jet nebulizer connected to the high flow nasal cannula.

Treatment:

Drug: Technetium-99m - Diethylenetriaminepentaacetic acid

Device: Jet Nebulizer

Other: Single photon emission computed tomography

Other: Spirometry