Tomography Positron Emission Assessment of the Impact of Cardiac Rehabilitation on Coronary Endothelial Function in Cardiac Failure (TEP-READ)

Caen University Hospital

Status: Completed

Conditions: Cardiac Failure

Treatments: Procedure: cardiac Rehabilitation; Other: Tomography Positron Emission

Study type: Interventional

Funder types: Other

Identifiers

NCT02524574

09-089

Details and patient eligibility

About

In patients with heart failure, the drive to the effort has demonstrated its safety and its interest. Patients with heart failure, endothelium-dependent peripheral vasodilatation is impaired by decreased activity of endothelial NO synthase. The rehabilitation training significantly improves peripheral endothelial function, and this improvement is correlated to the increase in exercise capacity. The impact on coronary endothelial function remains poorly documented, especially in non-ischemic dilated heart disease.

The main objective of this study is to investigate the effectiveness of cardiac rehabilitation on the restoration of coronary endothelial function in cardiac failure patient evaluated with Tomography Positron Emission 15O-H2O.

Enrollment: 54 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with heart failure with nonischemic dilated cardiomyopathy
• Class II-III NYHA (New York Heart Association)
• Having no contra-indication to the effort
• Fraction Ejection ≤ 40%
• patient who will have cardiac rehabilitation
• Age over 18 years
• informed consent signed
• patient with a social security scheme

Exclusion criteria

• Hypertension> 160/90 mmHg
• High cholesterol level > 6.0 mmol / l
• Diabetes known and treated
• Active smoking
• Valvular heart disease, congenital or ischemic
• Pregnant or breastfeeding women
• Age <18 years
• Major Adult guardianship

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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54 participants in 1 patient group

cardiac Rehabilitation

Experimental group

Treatment:

Other: Tomography Positron Emission

Procedure: cardiac Rehabilitation