Tongzhou Cohort Study

Capital Medical University

Status: Active, not recruiting

Conditions: Hypertension; Obesity

Treatments: Other: No intervention

Study type: Observational

Funder types: Other

Identifiers

NCT05156580

2021-P2-163-01

Details and patient eligibility

About

Long-term Impact of Overweight/Obesity and Hypertension on Cardiovascular Risk in Middle-aged and Elderly Adults

Full description

Overweight and obesity are major risk factors associated with the development of hypertension, poor blood pressure control, and adverse cardiovascular outcomes. However, evidence regarding the long-term impact of overweight/obesity and hypertension on cardiovascular risk in middle-aged and elderly populations remains limited. Therefore, the present study aims to evaluate the long-term effects of overweight/obesity and hypertension on cardiovascular risk in middle-aged and elderly adults.Additionally, a subgroup analysis will be conducted in participants with sarcopenia to assess the influence of blood pressure on prognosis, exploring potential interactions between muscle loss, hypertension, and cardiovascular outcomes.

Enrollment: 31,080 patients

Sex: All

Ages: 45+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Ages of ≥ 45 years
• Participants from routine health examinations at Tongzhou Community Health Service Center
• Availability for follow-up until 2026
• No major barriers to provide written consent

Exclusion criteria

• NA

Trial design

31,080 participants in 6 patient groups

Obese hypertensive group

Description:

Patients who were diagnosed with obesity (body mass index (BMI)≥28kg/m2) and hypertension (systolic blood pressure (SBP)/diastolic blood pressure (DBP) ≥ 140/90 mmHg).

Treatment:

Other: No intervention

Overweight hypertensive group

Description:

Overweight patients (24 kg/m2≤BMI≤28 kg/m2) diagnosed with hypertension (SBP/DBP≥140/90 mmHg).

Treatment:

Other: No intervention

Lean hypertensive group

Description:

Lean patients (BMI ≤ 24 kg/m2) diagnosed with hypertension (SBP/DBP ≥ 140/90 mmHg).

Treatment:

Other: No intervention

Lean normotensive

Description:

Lean patients (BMI ≤ 24 kg/m2) diagnosed with normotensive (SBP/DBP \< 140/90 mmHg).

Treatment:

Other: No intervention

Overweight normotensive

Description:

Overweight patients (24 kg/m2≤BMI≤28 kg/m2) diagnosed with normotensive (SBP/DBP\<140/90 mmHg)

Treatment:

Other: No intervention

Obese normotensive

Description:

Patients who were diagnosed with obesity (BMI≥28kg/m2) and normotensive (SBP/DBP\<140/90 mmHg).

Treatment:

Other: No intervention