Topical 5-ALA-PDT With Blu-U Therapy Versus Topical 5-ALA With Pulse Dye Laser In Treating Recalcitrant Acne Vulgaris

The University of Chicago

Status: Withdrawn

Conditions: Acne Vulgaris

Treatments: Drug: 5-ALA with Candela V-beam Pulse Dye Laser; Drug: 5-ALA with Blu-U Light

Study type: Interventional

Funder types: Other

Identifiers

NCT00814918

15929B

Details and patient eligibility

About

The goal of this study is to compare how efficient two different types of PDTs are when used in combination with topical 5-ALA. The two types of PDT lights are Blu-U light and Candela V-beam Pulse Dye Laser.

Sex: All

Ages: 18 to 79 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18-79 years of age
• Patients who failed the topical and oral antibiotics after 6 month therapy.
• Patients who failed the topical retinoids after 6 month therapy.
• Patients that are not good candidate to start oral isotretinoin (Accutane) due to contraindications.

Exclusion criteria

• Patients who have had Isotretinoin therapy less that 1 year prior to this ALA-PDT procedure.
• Patients who have an adverse reaction to light exposure (for example photo- exacerbated seizures).
• Patients with a history of porphyria.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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0 participants in 2 patient groups

1

Experimental group

Description:

5-ALA Application and exposure using Blu-U light to 1/2 of face.

Treatment:

Drug: 5-ALA with Blu-U Light

2

Experimental group

Description:

5-ALA Application and exposure using Candela V-beam Pulse Dye Laser to 1/2 of face.

Treatment:

Drug: 5-ALA with Candela V-beam Pulse Dye Laser