Topical 5% Minoxidil and Potent Topical Corticosteroid Versus Intralesional Corticosteroid in the Treatment of Alopecia Areata

Cairo University (CU)

Status and phase: Completed; Phase 4

Conditions: Alopecia Areata

Treatments: Drug: Triamcinolone Acetonide; Drug: clobetasol propionate; Drug: Minoxidil 5 % Topical Spray

Study type: Interventional

Funder types: Other

Identifiers

NCT03535233

AA22

Details and patient eligibility

About

Alopecia areata (AA) presents with circumscribed patches of non-scarring hair loss. It inflects a significant psychological and social burden. Many treatment options are used for the treatment of AA. Randomized controlled trials comparing intralesional and topical therapy and comparing combinations are few.

The aim of this work is to evaluate the efficacy of combined topical 5% minoxidil and potent topical corticosteroid therapy compared to intralesional triamcinolone injection in alopecia areata

Enrollment: 40 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients presenting with scalp alopecia areata, patchy type, of at least 2 months duration.

Exclusion criteria

• Alopecia totalis and alopecia universalis.
• Alopecia areata solely affecting the beard.
• Pregnant and lactating.
• Patients known to have autoimmune diseases e.g. autoimmune thyroid disease, vitiligo or SLE.
• Patients receiving systemic treatment relevant to alopecia areata within 3 months before enrollment into the study or topical treatment relevant to alopecia areata within 2 months before.
• Patients with a dermatological condition affecting the scalp other than AA: e.g. psoriasis, eczema.
• Patients with psychiatric illness or psychological state interfering with compliance or influencing the expectation of the patient.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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40 participants in 2 patient groups

Intralesional group

Active Comparator group

Description:

intralesional triamcinolone acetonide 5 mg/ml monthly

Treatment:

Drug: Triamcinolone Acetonide

Topical therapy group

Active Comparator group

Description:

Minoxidil 5% topical solution applied twice daily and topical clobetasol propionate 0.05% cream applied once daily every night

Treatment:

Drug: Minoxidil 5 % Topical Spray

Drug: clobetasol propionate