Topical 5% Tranexamic Acid as a Treatment for Postinflammatory Hyperpigmentation Due to Acne Vulgaris

Wayne State University

Status and phase: Withdrawn; Phase 3; Phase 2

Conditions: Postinflammatory Hyperpigmentation

Treatments: Drug: Tranexamic Acid; Drug: Vehicle

Study type: Interventional

Funder types: Other

Identifiers

NCT03361345

1709000866

Details and patient eligibility

About

The goal of this study is to determine if topical tranexamic acid is capable of decreasing the pigment of the dark spots left from acne bumps. The first line medication used for this often is not tolerated well by patients, and topical tranexamic acid has minimal reported side effects thus far.

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18 to 65
• Patients with bilateral involvement of facial postinflammatory hyperpigmentation due to acne vulgaris.

Exclusion criteria

• Pregnant patients or patients planning to become pregnant during the time of the study.
• Patients with a history of use of hydroquinone, kojic acid, tretinoin, adapalene, tazarotene or azaleic acid in the previous 3 months.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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0 participants in 2 patient groups

Right Side of Face

Experimental group

Description:

Patients will apply topical tranexamic acid to the dark spots on the one side of their face.

Treatment:

Drug: Tranexamic Acid

Left Side of Face

Sham Comparator group

Description:

Patients will apply the vehicle cream without any medication to the dark spots on one side of their face.

Treatment:

Drug: Vehicle