Topical Agents Containing Magnesium Sulfate & Wound Healing in the Rat Model

Başakşehir Çam & Sakura City Hospital

Status and phase: Unknown; Early Phase 1

Conditions: Wound Heal

Treatments: Drug: Centella asiatica; Other: Experimental drug 1; Other: sham comparator; Other: placebo comparator; Other: Experimental drug 2

Study type: Interventional

Funder types: Other

Identifiers

NCT04886882

SakuraDermatology1

Details and patient eligibility

About

An experimental study examining wound healing in 5 different groups on 30 rats.

Full description

Magnesium topically increases collagen synthesis and angiogenesis, providing faster and higher quality wound healing. In addition, with its analgesic effect, it will also eliminate the pain sensation caused by the wound and increase the quality of life of the patient whose skin integrity is impaired.

Enrollment: 30 estimated patients

Sex: Female

Ages: 8 to 12 weeks old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy rats between ages of 8- 12 weeks

Exclusion criteria

• weight loss of more than 15% of body weight

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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30 participants in 5 patient groups, including a placebo group

Group placebo

Placebo Comparator group

Description:

Isotonic solution will be administered daily to 6 female rats.

Treatment:

Other: placebo comparator

Group sham

Sham Comparator group

Description:

Base cream to be applied twice a day to 6 female rats.

Treatment:

Other: sham comparator

Group %1 mgso4

Experimental group

Description:

Cream containing 1% MgSO4 will be applied twice a day to 6 female rats.

Treatment:

Other: Experimental drug 1

Group %10 MgSO4

Experimental group

Description:

Cream containing 10% MgSO4 will be applied twice a day to 6 female rats.

Treatment:

Other: Experimental drug 2

Group positive control

Active Comparator group

Description:

Cream containing centella asiatica will be applied twice a day to 6 female rats.

Treatment:

Drug: Centella asiatica