Topical Analgesic Versus Saline Mouth Rinses in Post Extraction Healing

Aga Khan University

Status and phase: Completed; Early Phase 1

Conditions: Tooth Extraction Site Healing

Treatments: Drug: Normal saline; Drug: Aspirin Powder

Study type: Interventional

Funder types: Other

Identifiers

NCT03130153

3425-Sur-ERC-14

Details and patient eligibility

About

There is no evidence based guidelines on using saline rinses for post extraction oral care among hypertensives. Similarly, benefit of orally dissolved topical analgesics in addition to orally administered analgesic is questionable.

Full description

Objective: To compare the post dental extraction healing among subjects who took simple analgesic tablets dissolved in water versus those who used saline rinses post operatively.

Methods: A study will be done among patients who underwent dental extractions at AKHSP dental clinic, Karachi, Pakistan. Carious, periodontally mobile, traumatized or broken down teeth among 20-70 years old in either gender will be included.

In addition to the routine prescription of antibiotics and oral analgesics, the hypertensive subjects (n=20) will be advised to take dissolved Aspirin tablet as an oral care while non-hypertensive will be divided into two sub groups (n=20 each), advised saline mouth rinses or dissolved Aspirin for 5 days, respectively.

The outcome (healing of the extraction socket) will be evaluated 7 days from the day of extraction on an ordinal scale.

Enrollment: 60 patients

Sex: All

Ages: 20 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Carious, periodontally mobile, traumatized or broken down teeth needing extraction
• Age 20-70 years, both genders

Exclusion criteria

• Diabetes
• Osteoporosis, metabolic bone disease etc.
• Radiation therapy or chemotherapy.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 3 patient groups

hypertensives on Aspirin mouthwash

Experimental group

Treatment:

Drug: Aspirin Powder

non-hypertensives on Aspirin mouthwash

Active Comparator group

Treatment:

Drug: Aspirin Powder

hypertensives on Saline mouthwash

Active Comparator group

Treatment:

Drug: Normal saline