Topical Antibiotics for Prevention of Intensive Care Unit (ICU) Central Line Infections (ToPICL)

Fraser Health

Status: Withdrawn

Conditions: Skin Diseases, Infectious; Blood Stream Infections

Treatments: Drug: Polysporin Triple Therapy ointment; Other: Petroleum Jelly

Study type: Interventional

Funder types: Other

Identifiers

NCT00990392

Kerrie-333333

Details and patient eligibility

About

The purpose of the study is to determine if the overall central venous catheter related infection rate can be reduced by the application of Polysporin Triple Therapy ointment to the insertion site.

Full description

Previous studies in the dialysis population have found a reduction in local and system central venous catheter related infections with the application of topical antibiotics to the insertion point. One such study found a mortality benefit with Polysporin Triple Therapy ointment. We intend to determine if this preparation can reduce overall line infection rates in the ICU environment through its application at the time of line insertion and twice more the following week.

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• all patients admitted to the ICU requiring a central venous catheter

Exclusion criteria

• previous line infection during same ICU stay
• CVC for hemodialysis

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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0 participants in 2 patient groups, including a placebo group

Polysporin Triple Therapy

Experimental group

Description:

Polysporin Triple Therapy ointment applied to the insertion point at the time of CVC placement and twice within the first week.

Treatment:

Drug: Polysporin Triple Therapy ointment

Placebo

Placebo Comparator group

Description:

Petroleum jelly

Treatment:

Other: Petroleum Jelly