Topical Capsaicin for Cyclical Vomiting

Henry Ford Health

Status and phase: Completed; Phase 2

Conditions: Cyclical Vomiting

Treatments: Drug: Placebos; Drug: Capsaicin 0.1% Cream

Study type: Interventional

Funder types: Other

Identifiers

NCT03223350

10658 (Registry Identifier)

Details and patient eligibility

About

This is a phase 2 randomized controlled trial testing the effect of topical capsaicin for the relieve of nausea and vomiting.

Enrollment: 30 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• suspected cyclical vomiting syndrome / cannabinoid hyperemesis
• active severe nausea or vomiting in the emergency department

Exclusion criteria

• pregnant women, children < 18 years, no prior history of similar symptoms, suspected surgical or infectious cause of symptoms, suspected hepatitis or pancreatitis, allergy to capsaicin or hot peppers, chronic use of prescription antiemetic in prior 24 hours, abdominal pain alone (without nausea or vomiting)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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30 participants in 2 patient groups, including a placebo group

Capsaicin

Experimental group

Description:

0.1% capsaicin cream, one application

Treatment:

Drug: Capsaicin 0.1% Cream

Placebo

Placebo Comparator group

Description:

Topical cream with no active drug

Treatment:

Drug: Placebos