Topical Corticosteroids on the Incidence of Postinflammatory Hyperpigmentation After QsNdYAG Laser

Mahidol University

Status: Completed

Conditions: Post Inflammatory Hyperpigmentation; Lentigines

Treatments: Device: Q switched Nd:YAG laser 532 nm; Drug: topical 0.05% Clobetasol propionate ointment

Study type: Interventional

Funder types: Other

Identifiers

NCT02492373

Si 033/2015

Details and patient eligibility

About

To investigate the benefit of the application of topical high potency steroid on the incidence of post inflammatory hyperpigmentation after laser treatment.

Full description

• The incidence of post inflammatory hyperpigmentation (PIH) after treating lentigines with Q-switched Nd:YAG laser was 78.3%.
• It has been found that the incidence of PIH decreased to 40% after applied topical high potency steroid 2 days after the laser treatment.
• By these anti-inflammatory and anti-PIH effects of the high potency steroid, the investigators aimed that the application of steroid 2 days before and 2 days after the laser treatment would be better reduction in the incidence of PIH after Q-switched Nd:YAG laser.

Enrollment: 21 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Having multiple lentigines on both sides of the face
• Fitzpatrick skin phototype 3-5

Exclusion criteria

• Patients with lesions with any clinical suspicion of being pre-cancerous or skin malignancies of any kind
• Patients who have photosensitive dermatoses
• Pregnancy and lactation woman
• Patients with wound infections (herpes, other) on the day of treatment
• Patients with moderate and severe inflammatory acne, Immunosuppressed patients, history of vitiligo
• Patients with unrealistic concerns/expectations and inability to do the appropriate post-operative care

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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21 participants in 2 patient groups

laser+steroid 2 days before and after laser

Active Comparator group

Description:

Before lentigines' treatment with Qs Nd:YAG 532 nm laser, topical 0.05% Clobetasol propionate ointment was applied 2 days on the lesion. Then applied 2 days after the treatment.

Treatment:

Drug: topical 0.05% Clobetasol propionate ointment

Device: Q switched Nd:YAG laser 532 nm

laser+steroid 2 days after laser

Other group

Description:

Controlled side. Applied topical 0.05% Clobetasol propionate ointment only 2 days after the laser treatment

Treatment:

Drug: topical 0.05% Clobetasol propionate ointment

Device: Q switched Nd:YAG laser 532 nm