Topical Garlic Concentrate for Alopecia Areata in Children

E

Elena Pope

Status and phase

Terminated
Phase 3

Conditions

Alopecia Areata

Treatments

Drug: garlic concentrate

Study type

Interventional

Funder types

Other

Identifiers

NCT02691117
1000050555

Details and patient eligibility

About

Management of pediatric alopecia is particularly challenging given the chronicity of the condition, limited therapeutic response and devastating psychological effects. There is a paucity of safe and effective therapies in this population. The investigators propose to conduct and open label, prospective cohort pilot study using topical garlic concentrate ( GarlicRich) for treatment of children with alopecia areata. Study medication will be applied topically on affected area of the skin daily for 6 months. Follow up visits will occur monthly to access the efficacy and safety of the proposed treatment .

Full description

The investigators are planning to enroll in the study 20 participants at Sickkids. It is an open label, prospective cohort pilot study. Patients enrolled in the study will be followed at the Hospital for Sick Children for 6 months. Participants will come for the study visits every month (7 study visits). During each study visit two investigators will independently access patient's hair density and calculate the SALT score (Severity of Alopecia Tool Score), using the participant's digital photographs. Patients will be provided with the study medication for all duration of the study. The results of the treatment will be compared with the baseline data ( pictures/ scores/ hair density) to evaluate the efficacy and safety of garlic concentrate in children with patchy alopecia areata.

Enrollment

8 patients

Sex

All

Ages

4 to 18 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Children aged 4 years and older up to 18 years of age
  • Patches of alopecia areata that affect less than 50% of the scalp.
  • Alopecia of at least 1 year duration without evidence of regrowth
  • Informed written consent

Exclusion criteria

  • Any children experiencing significant spontaneous regrowth of terminal hair at the baseline visit.
  • Any children treated with a topical, (including shampoos with active ingredients like minoxidil or clobetasol), intralesional or systemic agent likely to cause regrowth in alopecia areata within the past month from the baseline visit and during study period.
  • Children with history of hypersensitivity to garlic.
  • Children with widespread alopecia areata as alopecia totalis, universalis, ophiasis or diffuse Alopecia Areata.

Trial design

Primary purpose

Treatment

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

8 participants in 1 patient group

Garlic concentrate
Experimental group
Description:
Garlic gel concentrate- once a day topical application
Treatment:
Drug: garlic concentrate

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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