Topical Hydromorphone for Wound Healing

Hordinsky, Maria K., MD

Status and phase: Terminated; Phase 2; Phase 1

Conditions: Wound Healing

Treatments: Drug: hydromorphone

Study type: Interventional

Identifiers

NCT00177060

0308M50994

Details and patient eligibility

About

The hypothesis is that topical opioids will hasten wound healing in humans.

Full description

This is based on our published data that morphine is a powerful stimulant of angiogenesis and our preclinical study of wounds in rats which demonstrate that topical opioids (morphine, hydromorphone and fentanyl) hasten healing of punch biopsy wounds. This study will focus on hydromorphone which was more powerful than morphine as a wound-healer in the rat study.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Self-identified as normal, healthy volunteers age 18-65.

Exclusion criteria

• Known bleeding disorder.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Single Blind