Topical Metronidazole vs Control in Reducing Periodontal Pockets in a Split Mouth Clinical Trial (Perio_topic)

University of Salamanca

Status and phase: Completed; Phase 4

Conditions: Periodontal Disease; Periodontal Inflammation

Treatments: Drug: Topical Gel; Procedure: Root scaling

Study type: Interventional

Funder types: Other

Identifiers

NCT06836401

USAL_Nº201700008745

Details and patient eligibility

About

The effect of both the mechanical treatment and the topical metronidazol in reduccing the inflammation and depth of the periodontal pockets were assessed on the first bicuspids.

Enrollment: 20 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Periodontal patients with all first premolars suffering from moderate periodontal pockets (>4mm of probing depth)

Exclusion criteria

• No patients received antibiotics nor periodontal treatment in the previous 6 months

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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20 participants in 2 patient groups

Metronidazole

Experimental group

Description:

These periodontal pockets will be treated with a metronidazole-based gel

Treatment:

Procedure: Root scaling

Drug: Topical Gel

Carbopole

Sham Comparator group

Description:

These deep periodontal pockets (\>4mm) are treated with a placebo gel made of carbopol gel

Treatment:

Procedure: Root scaling

Drug: Topical Gel