Topical Tranexamic Acid After Intravitreal Injections

Rambam Health Care Campus

Status: Unknown

Conditions: Subconjunctival Hemorrhage

Treatments: Other: Balanced Salt Solution; Drug: Tranexamic acid

Study type: Interventional

Funder types: Other

Identifiers

NCT04400916

0424-19-RMB

Details and patient eligibility

About

We aim to investigate whether topical administration of Tranexamic acid can reduce the occurence of subconjunctival hemorrahge after routine intravitreal injections for retinal conditions.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Subjects receiving intravitreal injections as part of their routine ophthalmological care

Exclusion criteria

Pregnancy, Oral contraceptives/HRT use, Known systemic autoimmune disease, Renal failure, active/suspected infection or inflammation in the treated eye, subconjunctival hemorrahge prior to inclusion, History of subarachnoid hemorrahge, thromboembolic events, increased risk for thromboembolic events, known sensitivity to the study drug

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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100 participants in 2 patient groups, including a placebo group

Topical tranexamic acid

Experimental group

Treatment:

Drug: Tranexamic acid

Topical BSS

Placebo Comparator group

Treatment:

Other: Balanced Salt Solution