Topical Tranexamic Acid for the Prevention of Postpartum Hemorrhage in Women Undergoing Elective Cesarean Section

Aswan University Hospital

Status: Unknown

Conditions: Cesarean Section Complications

Treatments: Other: : normal saline; Drug: Topical tranexamic acid

Study type: Interventional

Funder types: Other

Identifiers

NCT05072860

aswu/542/7/21

Details and patient eligibility

About

In hypertensive women having an elective cesarean section, the effectiveness and safety of temporary uterine packing coupled with topical tranexamic acid as an adjuvant for decreasing blood loss during delivery were compared to placebo.

Full description

patients were allocated to one of two groups after induction of anesthesia. they received temporary uterine packing with gauze of the dimensions soaked with 2 gm tranexamic diluted in 60ml saline acid or placebo

Enrollment: 150 estimated patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• hypertensive women undergoing elective cesarean section

Exclusion criteria

• Patients with cardiac, hepatic, renal, or thromboembolic disease. ,
• patients with the high possibility of the morbid adherent placenta,
• known coagulopathy and
• those presented with severe antepartum hemorrhage
• refuse to participate

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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150 participants in 2 patient groups, including a placebo group

Topical tranexamic acid

Experimental group

Description:

temporary uterine packing with gauze of the dimensions soaked with 2 gm tranexamic diluted in 60ml saline acid or placebo

Treatment:

Drug: Topical tranexamic acid

normal saline

Placebo Comparator group

Description:

temporary uterine packing with gauze of the dimensions soaked with 2 gm placebo to tranexamic diluted in 60ml saline acid

Treatment:

Other: : normal saline