Topical vs Oral Metronidazole After Benign Anorectal Surgery

Mansoura University

Status: Completed

Conditions: Anal Fissure; Anal Fistula; Hemorrhoids

Treatments: Drug: Topical metronidazole; Drug: oral metronidazole

Study type: Interventional

Funder types: Other

Identifiers

NCT05038605

Mansoura2021

Details and patient eligibility

About

While some investigators found oral metronidazole to be effective in reducing pain after hemorrhoidectomy, other researchers did not find a significant analgesic effect of systemic metronidazole. On the other hand, topical application of metronidazole had more consistent favorable results as Ala et al documented a remarkable analgesic effect of topical metronidazole 10% after excisional hemorrhoidectomy which was in line with Nicholson and Armestrong who also concluded similar results.

No previous study compared the analgesic effect of topical and oral metronidazole after anorectal surgery. Therefore, the present trial was conducted to compare the impact of oral versus systemic metronidazole on pain and recovery after surgery for benign anorectal conditions.

Enrollment: 108 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients of either sex aged below 70 years
• Underwent surgery for hemorrhoids, anal fissure, or simple anal fistula.

Exclusion criteria

• Grade I-II hemorrhoids.
• acute anal fissure.
• complex anal fistula
• perianal abscess
• perianal Crohn's disease
• malignancy.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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108 participants in 3 patient groups

Topical metronidazole

Active Comparator group

Description:

Topical application of metronidazole cream on the anal verge after surgery

Treatment:

Drug: Topical metronidazole

Oral metronidazole

Active Comparator group

Description:

oral metronidazole 500 mg tablets after surgery

Treatment:

Drug: oral metronidazole

Control

No Intervention group

Description:

No metronidazole was received