Topiramate and Cerebrovascular Response in Migraineurs

Seoul National University

Status and phase: Completed; Phase 4

Conditions: Migraine Disorders

Treatments: Drug: Topiramate

Study type: Interventional

Funder types: Other

Identifiers

NCT02424318

06-2008-71

Details and patient eligibility

About

The purpose of this study is to evaluate the effect of topiramate on cerebrovascular reactivity and mean flow velocity to photic stimulation in migraineurs.

Enrollment: 19 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• aged 18 to 65 years
• newly-diagnosed patients with migraine without aura (International Headache Society classification)
• symptom frequency (at least 2 episodes of migraine attack/month)

Exclusion criteria

• prior use of preventive medication
• patients with cardiovascular risk factors (hypertension, diabetes, hyperlipidemia, smoking)
• patients who take antihypertensive agent or antidepressant
• patients who were pregnant, breast-feeding or actively smoking
• patients with neurological or cerebrovascular diseases

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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19 participants in 1 patient group

Topiramate

Experimental group

Description:

topiramate 25mg twice for 1 week -\> topiramate 50mg twice for 7 weeks

Treatment:

Drug: Topiramate