Topotecan and Melphalan for Retinoblastoma

Sun Yat-sen University

Status and phase: Enrolling; Phase 3

Conditions: Chemotherapy Effect; Retinoblastoma

Treatments: Drug: Melphalan; Drug: Topotecan

Study type: Interventional

Funder types: Other

Identifiers

NCT04799002

202103

Details and patient eligibility

About

The purpose of this study is to evaluate topotecan and melphalan for retinoblastoma patients.

Full description

To evaluate the effectiveness and complications of topotecan and melphalan for intraocular injection in retinoblastoma patients.

Enrollment: 50 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• diagnosed as retinoblastoma
• receiving eyeball-sparing treatment

Exclusion criteria

• disease progression during follow-up

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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50 participants in 2 patient groups

Topotecan

Active Comparator group

Description:

Topotecan intraocular injection during chemotherapy

Treatment:

Drug: Topotecan

Melphalan

Experimental group

Description:

Melphalan intraocular injection during chemotherapy

Treatment:

Drug: Melphalan