Toripalimab as Monotherapy in Participants With POLE or POLD-1 Mutated and Non-MSI-H Advanced Solid Tumors

Sun Yat-sen University

Status and phase

Enrolling

Phase 2

Conditions

Advanced Cancer

Solid Tumor

Treatments

Drug: Toripalimab

Study type

Interventional

Funder types

Other

Identifiers

NCT03810339

PPM

Details and patient eligibility

About

The purpose of this study is to evaluate the response of toripalimab (JS001), a PD1 antibody, in participants with POLE or POLD-mutated and non microsatellite instability (non-MSI-H) advanced solid cancers.

Full description

Immune checkpoint inhibitor (ICI) therapy including antibodies targeting PD-1/PD-L1 or CTLA-4 has greatly advanced the cancer treatments. Recent studies have identified several predictive markers for ICI which includes microsatellite instability (MSI), PD-L1 expression and tumor mutation burden (TMB). DNA polymerase epsilon (POLE) and delta (POLD) are in charge of DNA replication as well as proofreading during DNA replication. Their germline or somatic mutations can lead to DNA repair deficiencies and carcinogenesis. The investigators has found that the POLE or POLD mutation causes an increased TMB in cancer patients and may lead to a better survival to ICI. Therefore, the purpose of this study is to evaluate the efficacy of toripalimab , a PD1 antibody, in participants with POLE or POLD-mutated and non microsatellite instability high (non-MSI-H) advanced solid cancers. This is a Phase II, open label, single arm study. Participants enrolled in this study received toripalimab 240mg, every 3 weeks until disease progress or intolerable toxicity. Primary endpoints is ORR and secondary endpoints are OS, PFS and safety.

Enrollment

35 estimated patients

Sex

All

Ages

18 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Participants must provide written informed consent to participate
Adult aged between 18 and 75 years old
Participants with Histologically- or cytologically- proven advanced solid tumors and not responding to standard therapy
MSS (microsatellite sability) or MSI-L (microsatellite instability-low) or pMMR status
Germline mutations or somatic mutations in POLE or POLD (synonymous mutation is excluded)
Patients refuse any conventional chemotherapy or targeted therapy
Patients are willing to take biopsy of tumor tissue and take blood samples before treatment (blood samples are also taken at each time of therapeutic evaluation)
Participants must have at least one measurable site of disease according to Response Evaluation Criteria in Solid Tumors (RECIST) criteria. Lesions previously treated with radiotherapy should not be regarded as target lesions unless there is a definite progression of the lesion after radiotherapy.
Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1
Estimated life expectancy is greater than 3 months
Participants can provide more than 10 paraffin sections of tumor tissue
No history of radiotherapy or received non-targeted radiotherapy outside the target lesions for this study more than 4 weeks ago before the first dose of study treatment
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 2.5 x (5 x in participants with liver metastasis) upper limit of normal (ULN)
Albumin ≥ 3 g/dL
Alkaline phosphatase ≤ 2.5 x ULN.
Serum bilirubin <1.5 mg/dL
Creatinine ≤ ULN.
Absolute neutrophil count ≥ 1.5X10E9/L
Platelets ≥ 100 x 10E9/L
Hemoglobin ≥ 90 g/L
For females of childbearing potential (defined as <2 years after last menstruation or not surgically sterile), a negative serum pregnancy test must be performed within 21 days of the first dose of study treatment.
For females: agreement to contraception during the study treatment period and for at least 28 days after the last dose of study treatment

Exclusion criteria

Patients with confirmed or suspected brain metastases
Patients with cancerous meningitis
Patients without germline mutations or somatic mutations in POLE and POLD
MSI-H (microsatellite instability-high) or dMMR
Prior treatment with PD-1 inhibitors, PD-L1 inhibitors or CTLA-4 inhibitors (or other inhibitors in T cell co-stimulatory signals or checkpoint pathways)
Known history or evidence of cytotoxic drug therapy, biologic drug therapy (such as monoclonal antibodies), immunotherapy (such as interleukin 2 or interferon), or other investigational drugs therapy in the 4 weeks before the first dose of study treatment
Known history or evidence of significant immunodeficiency (including but not limited to: interstitial pneumonia, uveitis, enteritis, hepatitis, pituitary inflammation, nephritis, hyperthyroidism and hypothyroidism; Patients with vitiligo or asthma completely relieved can be included. Asthma that requires medical intervention cannot be included)
Patients with a condition requiring systemic treatment with either corticosteroids (> 10 mg daily prednisolone equivalent) or other immunosuppressive medications
Patients with active tuberculosis. Known history of antituberculosis drugs treatment in 1 year before the first dose of study treatment
Administration of an anti-infection vaccine (e.g. influenza vaccine, chickenpox vaccine) in the 4 weeks before the first dose of study treatment
Symptomatic heart failure, coronary heart disease (CHD), myocardial infarction in the 6 months before the first dose of study treatment
Known allergy to JS001 or its excipients
Pregnant or breastfeeding females
Other prior malignancy active within the previous 5 years except for non-melanoma skin cancer
Persons without legal capacity
Positive test for HIV or AIDS
Positive test for HbsAg and HBV-DNA copy numbers (≥ 1000cps/ml)
Positive test for HCV
Any medical disorder or condition that, in the opinion of the investigator, may affect the compliance or the signing of informed consent, etc.