Total Arterial Revascularization (TAR)

Meshalkin Research Institute of Pathology of Circulation

Status: Unknown

Conditions: Coronary Artery Disease; Coronary Artery Bypass Grafting

Treatments: Procedure: In-Situ; Procedure: Y-Graft

Study type: Interventional

Funder types: Other; NETWORK

Identifiers

NCT03753048

TAR

Details and patient eligibility

About

Total arterial revascularisation with in-situ confihuration of BITA is superior than y-graft in patients underwent CABG.

Full description

The main hypothesis of the trial is that in-situ configuration of bilateral internal thoracic arteries is superior than Y-graft configuration for MACCE (mortality, myocardial infarction, repeat revascularization, stroke) during mid-term follow-up in patients with CAD who is shedueled for CABG.

Enrollment: 880 estimated patients

Sex: All

Ages: 25 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Coronary Artery Disease
• Stable angina
• The need for revascularization of anterior descending and obtuse margin arteries accoring to the 2018 ESC/EACTS Guidelines on myocardial revascularization
• Informed Consent Form

Exclusion criteria

• The diameter of the target arteries is less than 1 mm
• Stenosis of the subclavian arteries more than 60%
• STEMI less than 3 month
• Previous cardiac surgery
• BMI >35
• COPD with FEV1 <60%
• Concomitant pathology that requires simultaneous surgical treatment
• Cancer with life expectancy less than 5 years

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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880 participants in 2 patient groups

Y-Graft

Active Comparator group

Description:

The group includes patients who underwent CABG in Y-Graft Configuration.

Treatment:

Procedure: Y-Graft

In-Situ

Active Comparator group

Description:

The group includes patients who underwent CABG in In-Situ Configuration.

Treatment:

Procedure: In-Situ