Total-body 13N-NH3 PET/CT to Study the Blood Perfusion in Whole Body

Shanghai Jiao Tong University

Status: Enrolling

Conditions: Cardiac Output

Treatments: Device: total-body PET/CT(uEXPLORER , United Imaging Healthcare, China)

Study type: Observational

Funder types: Other

Identifiers

NCT04941248

KY2021-086

Details and patient eligibility

About

The aim of our study is to analyze and quantitate whole-body blood perfusion by total-body 13N-NH3 PET/CT(uEXPLORER), and evaluate the influence to other organs caused by the decreased cardiac function.

Full description

Participants are invited to participate in a research that seeks to understand the dynamic blood perfusion in human body. The investigators expect to have twenty-five participants in this study at Renji Hospital, Shanghai. About sixteen of the participants will be patients who have been diagnosed with decreased cardiac function, nine participants will be healthy individuals with no known vascular disease. These healthy subjects will allow researchers to compare blood perfusion difference with those of persons with decreased cardiac function. All the participants will undergo the same procedure.

If participants agree to participate in this study, researchers will first interview participants and review the past medical record in order to document the medical history. When the screening procedures confirm that participants are eligible to participate in the study, participants will receive one dose of the non-therapeutic administration of a radioactive tracer called N-13 ammonia(13NH3) , then undergo one total body 13NH3 PET/CT Scan (uEXPLORER) to determine the blood flow value of the brain, kidney and other organs. The total body 13NH3 PET/CT Scan will allow investigators to observe and analyze the real-time blood flow differences between patients with between healthy controls and decreased cardiac function.

Enrollment: 25 estimated patients

Sex: All

Ages: 60 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Nine healthy volunteers with normal EF values
• Patients with decreased cardiac function, while their heart function grading above II(New York Heart Association,NYHA)
• Aged 60~90 years old
• Written informed consents will be offered and signed by all participants

Exclusion criteria

• History of vascular-related diseases in other organs
• Severe liver and kidney dysfunctions
• Patients who are pregnant or breast feeding
• People under the age of 60 years old
• Heart function grading below II(NYHA)
• inability to lie or to maintain posture in the scanner for one hour

Trial design

25 participants in 2 patient groups

Healthy controls

Description:

All healthy subjects will undergo the following intervention: 13N-NH3 PET/CT scan on the total-body uEXPLORER scanner.

Treatment:

Device: total-body PET/CT(uEXPLORER , United Imaging Healthcare, China)

Patients with decreased cardiac function

Description:

All patients will undergo the following intervention: 13N-NH3 PET/CT scan on the total-body uEXPLORER scanner.

Treatment:

Device: total-body PET/CT(uEXPLORER , United Imaging Healthcare, China)