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The purpose of this study is to define the role of total body composition in the guidance of nutritional support and treatment monitoring in head and neck patients. Furthermore, the second aim of this study is to compare the clinical performance of dual energy X-ray absorptiometry as compared to CT in evaluating total body composition of patients.
Full description
In this 4-year cohort study, a total of 120 patients with stage III-IV head and neck cancer (squamous cell carcinoma) patient undergoing concurrent chemo-radiotherapy will be enrolled. Laboratory examination will be performed to evaluate the physiological change and treatment related toxicity, including BUN and Cr for hydration and renal function; complete blood cell and differential count, pre-albumin and albumin for nutrition, and C-reactive protein for inflammatory change. Both CT and dual energy X-ray absorptiometry (DXA) will be used to evaluate total body composition. CT is used to evaluate surface area of fat and muscle, and DXA is used to evaluate lean body mass, fat body mass and bone mineral content. MRI of the head and neck region is used for tumor staging of the head and neck cancer, monitoring the treatment response and detecting treatment related adverse effect.
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Inclusion criteria
Biopsy-proven head and neck (SCC), surgery of the primary tumor/lymph nodes is limited to incisional/excisional biopsy.
2010 7th edition AJCC stage III, IVA (T4N0-2) and IVB (any T, N3).
Well-informed and accepted treatment of CCRT.
Age 20-70 years old.
Negative pregnancy test for women of childbearing potential.
Adequate hematopoietic or organ function which is amenable for chemotherapy:
Ability to understand and willingness to be enrolled in our study and sign a written informed consent document
Exclusion criteria
120 participants in 1 patient group
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Data sourced from clinicaltrials.gov
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