Total Body Perfusion in Patients With Chest Pain (KOVERI)

Turku University Hospital (TYKS)

Status: Enrolling

Conditions: Coronary Artery Disease

Study type: Observational

Funder types: Other

Identifiers

NCT05825859

KOVERI

Details and patient eligibility

About

The Purpose of this study is to better understand changes in obstructive coronary artery disease in different organs other than the heart such as the brain and the kidneys using a new generation total body PET scanner.

Full description

Patients with chest pain and suspected CAD will be studied using total body PET imaging with O15-water perfusion imaging

Enrollment: 300 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Documented history of chest pain with CT imaging showing a potential for obstructive coronary artery disease
• Ability to sustain adenosine injection 0.14 mg/kg/min

Exclusion criteria

• Second or third degree AV-block without pacemaker
• Sick sinus syndrome
• Consumption of coffee or aminophylline within 12 hours of administration
• Recent use of dipyridmole or dipyridamole-containing medications
• Known hypersensitivity to adenosine
• Unstable acute MI or acute coronary artery syndrome, and prior cardiac transplantation
• Active wheezing and bronchospasm
• Sinus bradycardia with HR<40 bmp