Total Knee Arthroplasty and Clinical Findings

Karadeniz Technical University

Status: Completed

Conditions: Orthopedic Disorder; Pain, Joint; Radiography; Proprioception; Arthropathy of Knee

Treatments: Procedure: Total Knee Arthroplasty

Study type: Interventional

Funder types: Other

Identifiers

NCT04481711

2018-91

Details and patient eligibility

About

Knee osteoarthritis is a common disease that causes pain and loss of function. Total Knee Arthroplasty (TKA) is a frequently used surgical method in the treatment of severe knee osteoarthritis. The aim of this study was to investigate the effect of TKA on IL-6, TNF-α and IL-1β cytokine levels, pain intensity at rest and walking, knee joint valgity angle,malaligment, functional status and knee joint position sense.

Full description

Twenty-nine patients (female/male: 24/5) with grade 4 osteoarthritis were included in the TKA group (study group) and 22 patients (female/male:13/9) with <grade 4 osteoarthritis were included in the control group. Systemic venous blood samples of the patients were taken to evaluate the cytokine level (IL-6, TNF-α, IL-1). The Visual Analogue Scale was used to assess pain intensity, and the WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) score was used to evaluate the functional status. Valgity and malaligment measurements were calculated using antero-posterior X ray Digital goniometer was used to evaluate the knee joint position sense (at 35, 55 and 70 degrees knee flexion angles). Measurements were taken once from patients in the control group, and twice in pre-op and post-op sixth weeks from study group.

Enrollment: 51 patients

Sex: All

Ages: 45 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with grade 4 degeneration levels who had surgical indications between the ages of 45-75 were placed in the study group.
• Patients without surgical indication, lower than 4 OA severity included in the control group

Exclusion criteria

• Patients with surgical history of the ipsilateral side, neuropathic pain, loss of sensation, systemic, chronic and infectious disease were excluded from the study

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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51 participants in 2 patient groups

Study group

Experimental group

Description:

Twenty-nine patients (female/male: 24/5) with grade 4 osteoarthritis were included in the study group. These patients underwent total knee arthroplasty

Treatment:

Procedure: Total Knee Arthroplasty

Control group

No Intervention group

Description:

Twenty-two patients (female/male:13/9) with \<grade 4 osteoarthritis were included in the control group.