Total Occlusive Ionic Silver-containing Dressing vs Mupirocin Ointment Application vs Conventional Dressing in Elective Colorectal Surgery: Effect on Incisional Surgical Site Infection

Hospital General Universitario Elche

Status and phase: Completed; Phase 3

Conditions: Incisional Surgical Site Infections

Treatments: Procedure: ionic silver-containing dressing; Procedure: Mupirocin ointment application

Study type: Interventional

Funder types: Other

Identifiers

NCT02267122

Hospital General Elche

Details and patient eligibility

About

The patients were randomized into 3 groups: those patients undergoing a ionic silver-containing dressing (ISD) (Group 1), those undergoing a Mupirocin ointment application (MOA) (Group 2) and those using a conventional dressing (Group 3) in the surgical wound after finishing an elective colorectal surgery.

Enrollment: 147 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of colorectal neoplasms and plans to undergo an elective surgery with curative aims.
• Open surgical approach

Exclusion criteria

• Anastomotic leak
• Mortality
• Lost to follow-up

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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147 participants in 3 patient groups

ionic silver-containing dressing

Experimental group

Description:

After placing the staples, a ionic silver-containing dressing was placed covering the wound.

Treatment:

Procedure: ionic silver-containing dressing

Mupirocin ointment application

Experimental group

Description:

After placing the staples, a Mupirocin ointment application was placed covering the wound.

Treatment:

Procedure: Mupirocin ointment application

Conventional dressing

No Intervention group

Description:

After placing the staples, a conventional dressing, without application of any special gauze or ointment, was placed covering the wound