Towards a High-fat Feeding Intervention Study: Identification of Markers for Inflammation and Organ Damage

Maastricht University Medical Centre (MUMC)

Status: Completed

Conditions: Systemic Inflammatory Response Syndrome; Sepsis

Treatments: Procedure: Blood collection

Study type: Observational

Funder types: Other

Identifiers

NCT00519350

074016

Details and patient eligibility

About

Patients undergoing major surgery, trauma or burns are prone to develop an exacerbated inflammatory response, which is potentially lethal to the individual. Recently, the researchers' group showed in a rodent model of hemorrhagic shock that high-fat feeding administered before shock attenuates inflammation and reduces intestinal and hepatic damage. In the mechanism that underlies this protective effect, the release of cholecystokinin in gut wall and activation of efferent vagus bundles are crucial events. Before investigating the effect of high-fat nutrition in clinical setting, suitable markers of inflammation and organ damage need to be selected. In this study, blood will be collected in patients undergoing different types of operations. Consequently several markers for inflammation and organ damage will be determined. Hence, suitable parameters for a future high-fat intervention study will be selected.

Enrollment: 24 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• > 18 years
• elective liver / colon / femur surgery

Exclusion criteria

• Acute inflammation
• Chronic Obstructive Respiratory Disease
• Recent history of abdominal pain or diarrhea
• BMI < 18.5
• Alcohol or Drugs abuses
• Recent intake of antibiotics

Trial design

24 participants in 3 patient groups

I

Description:

Liver surgery

Treatment:

Procedure: Blood collection

II

Description:

Colon surgery

Treatment:

Procedure: Blood collection

III

Description:

Femur Fracture

Treatment:

Procedure: Blood collection