Towards Early Detection of Breast Cancer in High Risk Population (READ RISK)

University of Aberdeen

Status

Unknown

Conditions

Breast Cancer

Treatments

Biological: Blood test

Diagnostic Test: MRI scan

Study type

Observational

Funder types

Other

Identifiers

NCT05268913

2-102-21

Details and patient eligibility

About

Breast cancer is a major and growing health challenge, and the leading cause of cancer in women. As population obesity rates increase, the number of new breast cancer diagnosis continues to rise. Despite treatment advances, breast cancer remains an important cause of premature mortality, taking women in the prime of life. Although underlying susceptibility caused by mutation in the genes including BRCA1/2 is increasingly identified, current pre-symptomatic screening for the general population and those at high genetic risk remains sub-optimal, with high false negative and positive rates.

Alteration of breast lipid composition has been observed by us and others in patients with breast cancer and is thought to precede onset. We have developed and tested a novel method to allow a standard 3T MRI scanner to perform quantitative 3D mapping of specific lipid molecules in the breast.

We will investigate if this method can detect very early breast cancers, and compare the amount and spread of lipid composition in breast tissue of premenopausal women with very high genetic risk of breast cancer, women with breast cancer and women with obesity.

Enrollment

120 estimated patients

Sex

Female

Ages

18 to 55 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Women with BRCA1/2 genes:

female 18-55 years old, premenopausal
BRCA 1/2 gene carriers
not having any metabolic disorders (e.g., diabetes)
not on any long term medications that may affect lipid metabolism (e.g., statins)
BMI < 30

Women with breast cancer (no obesity):

females 18-55 years old, premenopausal
confirmed diagnosis of invasive ductal carcinoma of the breast
not having any metabolic disorders (e.g., diabetes)
not on any long term medications that may affect lipid metabolism (e.g., statins)
BMI < 30

Women with breast cancer (obesity):

BMI > 30
otherwise as women with breast cancer

Women with obesity:

females 18-55 years old, premenopausal
not having any metabolic disorders (e.g., diabetes)
not on any long term medications that may affect lipid metabolism (e.g., statins)
BMI > 30

Exclusion criteria