Towards Optimal Treatment of Marfan Syndrome (TOWER)

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Status: Enrolling

Conditions: Marfan Syndrome

Treatments: Other: Magnetic Resonance imaging (MRI) examination

Study type: Observational

Funder types: Other

Identifiers

NCT05944614

NL82669.018.22

Details and patient eligibility

About

The purpose of this study is to determine whether new magnetic resonance imaging techniques can be used as a biomarker of aortic disease severity in patients with Marfan syndrome.

Enrollment: 150 estimated patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• MFS patients with a known FBN1 mutation
• Between 18-50 years of age

Exclusion criteria

• Contraindication for MR imaging
• Mental retardation
• Pregnancy, or planned pregnancy during study period

Additional exclusion criteria healthy controls:

• History of aorta disease

Trial design

150 participants in 2 patient groups

Marfan Syndrome patients

Description:

Marfan Syndrome patients age 18-50 with a pathological FBN1 mutation

Treatment:

Other: Magnetic Resonance imaging (MRI) examination

Healthy volunteers

Description:

Age and gender matched healthy control patients without a history of aortic disease.

Treatment:

Other: Magnetic Resonance imaging (MRI) examination