Toxicogenomic and Immunocytotoxic Effects of Propofol and Isoflurane Anesthetics in Patients Undergoing Elective Surgery

UPECLIN HC FM Botucatu Unesp

Status and phase: Completed; Phase 4

Conditions: Types of General Anesthesia; Patients in Good Health; DNA Damage

Treatments: Drug: Comparison of two anesthetic drugs

Study type: Interventional

Funder types: Other

Identifiers

NCT00854178

upeclin/HC/FMB-Unesp-20

Details and patient eligibility

About

The purpose of this study is to evaluate if the anesthetics propofol and isoflurane can damage DNA, induce apoptosis, change expression of genes related to apoptosis and DNA repair and change cytokines profile in patients submitted to elective surgery.

Full description

It is expected that the results provide relevant information to understand the possible adverse effects of anesthetics and contribute to the establishment of strategies aimed at reducing the risks to exposed individuals.

Enrollment: 26 estimated patients

Sex: All

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients in good health American Society of Anesthesia status physical I
• elective minor surgery
• general anesthesia

Exclusion criteria

• smokers
• alcoholics
• previous medication or radiation

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

26 participants in 1 patient group

2

Experimental group

Treatment:

Drug: Comparison of two anesthetic drugs