Trace Element Repletion Following Severe Burn Injury

Vaud University Hospital Center

Status: Completed

Conditions: Trace Element Deficiency; Critical Illness; Nutritional Deficiency; Burn Injury

Treatments: Other: Trace elements replacement

Study type: Observational

Funder types: Other

Identifiers

NCT03204669

X21

Details and patient eligibility

About

Major burn patients are characterized by large exudative losses of Cu, Se and Zn. Trace element (TE) repletion has been shown to improve clinical outcome. The study aimed to check if our repletion protocols were achieving normalization of TE plasma concentrations of major burn patients and if the necessity for continuous renal replacement therapy (CRRT) might increase the needs.

Full description

Retrospective analysis of prospectively collected data in burn patients requiring intensive care (ICU) between 1999 and 2015. The cohort was divided into 4 groups according to the protocol changes. Period 1 (P1): 1999-2000, P2: 2001-2005, P3: 2006-2010, P4: 2011-2015. Changes consisted mainly in increasing TE repletion doses and duration. Demographic data, daily TE intakes and weekly plasma concentrations were retrieved for the first 21 ICU-days.

Enrollment: 139 patients

Sex: All

Ages: 14 to 86 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Burn injury involving ≥20% body surface (TBSA) (i.e. the threshold for intravenous TE repletion prescription)
• At least one TE plasma concentration during the ICU stay

Exclusion criteria

• Comfort care
• Admission >24h after burn injury