Tracheal Positive Pressure During High Flow Nasal Oxygen Administration in Critically Ill Patients: a Physiologic Study. (HPEEP)

Azienda Sanitaria-Universitaria Integrata di Udine

Status: Not yet enrolling

Conditions: Positive End Expiratory Pressure; Airway Disease; Critically Ill; Diaphragm Disease; High Flow Nasal Cannula; Acute Respiratory Failure

Treatments: Device: HIGH FLOW NASAL OXYGEN

Study type: Observational

Funder types: Other

Identifiers

NCT05467332

HPEEP

Details and patient eligibility

About

High flow nasal cannula administration in critically ill patients is frequently used to improve acute respiratory failure or to prevent respiratory failure after extubation.

It acts generating a mild positive pressure in the airways and by reducing respiratory effort of patients.

However to the best of our knowledge, no study to date has directly measured the amount of positive pressure generated in the trachea of patients.

The primary aim, therefore, of this study measures this positive pressure after extubation in critically ill patients.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: CRITICALLY ILL PATIENTS AFTER MECHANICAL VENTILATION LASTED AT LEAST 72 HOURS

• age 18-80 years

Exclusion Criteria:

• COPD stage >1 according to GOLD classification
• end stage organ disease (liver, kidney, heart, lung)
• neuromuscular disease
• neoplasm
• previous tracheostomy
• obesity with BMI > 35 Kg/m2
• non collaborative patient

Trial design

20 participants in 1 patient group

CRITICALLY ILL PATIENTS

Description:

CRITICALLY ILL PATIENTS AFTER INVASIVE MECHANICAL VENTILATION READY TO BE EXTUBATED.

Treatment:

Device: HIGH FLOW NASAL OXYGEN