Tracheostomized COPD Patients and Non Invasive Mechanical Ventilation

Fondazione Salvatore Maugeri

Status: Unknown

Conditions: Chronic Obstructive Pulmonary Disease (COPD)

Treatments: Other: WBC, biomarkers, TBA, chest X ray

Study type: Observational

Funder types: Other

Identifiers

NCT01285739

MS-12-2010

Details and patient eligibility

About

The purpose of this study was to determine occurrence of ventilator associated pneumonia (VAP) in tracheostomized patients with COPD discharged in invasive mechanical ventilation (IMV) compared to patients with CPOPD discharged with tracheostomy but in non invasive mechanical ventilation (NIMV).

Full description

Acute respiratory failure due to COPD is often treated with invasive mechanical ventilation through endotracheal intubation, followed by placement of a endotracheal canula. However, invasive ventilation is at risk of infective complications and is difficult to manage at home. In particular, invasive mechanical ventilation may be associated with ventilator associated pneumonia (VAP). VAP is usually suspected when the individual develops a new or progressive infiltrate on chest radiograph, leukocytosis, and purulent tracheobronchial secretions. When possible, we tried to put these tracheotomized patients in non invasive mechanical ventilation (NIMV)to avoid VAP. This population was followed for eight consecutive years and compared with patients in invasive home mechanical ventilation (IMV).

Enrollment: 247 patients

Sex: All

Ages: 50 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of COPD
• Tracheostomy
• Need of domiciliary invasive / non invasive ventilation

Exclusion criteria

• Patients with COPD weaned from invasive / non invasive mechanical ventilation
• Lack of tracheostomy

Trial design

247 participants in 2 patient groups

NIMV COPD

Description:

Patients with chronic obstructive pulmonary disease (COPD), who underwent tracheostomy for acute respiratory failure and who were discharged with tracheostomy but in domiciliary non invasive ventilation

Treatment:

Other: WBC, biomarkers, TBA, chest X ray

Other: WBC, biomarkers, TBA, chest X ray

IMV COPD

Description:

Patients with chronic obstructive pulmonary disease (COPD), who underwent tracheostomy for acute respiratory failure and who were discharged in domiciliary invasive mechanical ventilation (IMV)

Treatment:

Other: WBC, biomarkers, TBA, chest X ray

Other: WBC, biomarkers, TBA, chest X ray