Tracing Of Real-time glu13Cose Metabolism in Human Immune Cells (TORCH)

Vanderbilt University Medical Center

Status: Enrolling

Conditions: Metabolism; Immune System and Related Disorders; Isotope Labeling; Glucose

Treatments: Drug: 13C6-Glucose

Study type: Interventional

Funder types: Other

Identifiers

NCT06930976

241348

Details and patient eligibility

About

The purpose of this study is to understand how cells of the immune system use the common sugar glucose to fuel energy production and as a building block within the cell. Investigators will intravenously infuse a non-radioactive glucose tracer into participants over a few hours and collect immune cells from the blood to track uptake and usage of this glucose within these immune cells.

Enrollment: 12 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adults aged 18 or older

Exclusion criteria

• Pregnant
• Prisoner or in police custody
• Uncontrolled hyperglycemia/diabetes
• Current participation in another study where the total volume of blood drawn, when added to this study blood draw volume, exceeds 500cc in an 8 week period
• Any medical issue or pharmacologic exposure which, in the opinion of the study investigator, that might interfere with the study objectives
• Any reason which, in the opinion of the study investigator, adds additional risk to the participant

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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12 participants in 1 patient group

13C6-Glucose

Other group

Description:

10-25gm of 13C6-Glucose

Treatment:

Drug: 13C6-Glucose