Tractography and Diffusion Tensor Imaging of the Human Spinal Cord in Healthy Subjects : Anatomical Atlas (TRACTOCORD)

Civil Hospices of Lyon

Status: Completed

Conditions: Healthy Volunteer

Treatments: Procedure: Spinal cord Tractography in order to differentiate spinal tracts.

Study type: Interventional

Funder types: Other

Identifiers

NCT05079945

69HCL21_0265

2021-A02277-34 (Other Identifier)

Details and patient eligibility

About

Today, Spinal cord pathologies, whether are tumoral, vascular, traumatic, malformative, inflammatory, or degenerative still constitute a major medico-surgical challenge due to the particular anatomy of the spinal cord. Indeed, the spinal fibers (whether they have a sensory or motor function) are all condensed in an extremely small volume. To date, there is no reliable technique to know the precise position of the spinal tracts specifically involved in the sensory and motor functions of the upper and lower limbs.

The purpose of this study is to evaluate the feasibility for differentiating spinal tracts by tractography from a cerebral Diffusion tensor imaging (DTI) Magnetic Resonance Imaging (MRI) sequence (associated with an anatomical sequence) by performing a stitching process with spinal cord DTI MRI sequence, in healthy subjects. The criterion of differentiation of the tracts will be assessed by highlighting already known cerebral tracts (cortico-spinal fibers, spinothalamic, posterior cord) and which will be monitored at the spinal level.

Enrollment: 49 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• patient> 18 years old
• Healthy volunteer
• Social insured in France
• Patient who signed the informed consent of the study

Exclusion criteria

• Medical or surgical history of disease that may affect the central nervous system, or the spine
• History of spine or spinal cord trauma.
• Spinal osteoarthritis which can lead to a medullary hyper signal.
• Contraindication to MRI: claustrophobia, pace-maker, defibrillator, metallic foreign bodies, etc.
• Subjects benefiting from legal protection (curatorship, guardianship or safeguard of justice).
• Pregnant and / or breastfeeding woman.

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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49 participants in 1 patient group

Spinal cord Tractography

Experimental group

Description:

Healthy volunteer having the tractography exam

Treatment:

Procedure: Spinal cord Tractography in order to differentiate spinal tracts.