ClinicalTrials.Veeva

Menu

TRAIN-BW: Backward Walking Training in Multiple Sclerosis

Wayne State University logo

Wayne State University

Status

Enrolling

Conditions

Gait Disorders, Neurologic
Multiple Sclerosis
Accidental Fall

Treatments

Behavioral: Backward Walking Training
Behavioral: Forward Walking Training

Study type

Interventional

Funder types

Other

Identifiers

NCT04091464
URG20192020

Details and patient eligibility

About

Individuals with multiple sclerosis (MS) experience in impairments in mobility and cognition that increase the risk for accidental falls. More than 50% of individuals with MS experience injurious falls within a 6-month period. Current interventions to improve fall risk have focused on forward walking (FW) and balance training, resulting in small declines in the relative risk for falls with a large degree of variability. Interestingly, motor differences between MS and healthy controls are more pronounced in backward walking (BW), yet no studies have investigated BW training as an intervention to reduce fall risk in persons with MS. This study will investigate the feasibility, acceptability and impact of BW training compared to forward walking training on motor function and fall risk in persons with MS.

Enrollment

90 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Diagnosis of MS
  • PDDS <6, indicating ability to ambulate with or without an assistive device >/= 50% of the time
  • Self-reported walking dysfunction as evidenced by a score of >/= 30 on MSWS-12 OR reports of 2 or more falls in the prior 6 months, indicating a frequent faller.

Exclusion criteria

  • MS relapse within the past 30 days
  • comorbid neurological disorder
  • acute orthopedic disorder/injury
  • unable to follow study-related commands

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

90 participants in 2 patient groups

TRAIN-BW
Experimental group
Description:
1x/week for 8 weeks + home exercise program
Treatment:
Behavioral: Backward Walking Training
TRAIN-FW
Active Comparator group
Description:
1x/week for 8 weeks + home exercise program
Treatment:
Behavioral: Forward Walking Training

Trial contacts and locations

1

Loading...

Central trial contact

Nora Fritz, PhD

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2025 Veeva Systems