Trait Anxiety and Defensive Networks

University of Electronic Science and Technology of China

Status: Completed

Conditions: Healthy

Treatments: Drug: Oxytocin; Behavioral: trait anxiety scale; Drug: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT02682888

UESTC-neuSCAN_20

Details and patient eligibility

About

to examine the association between trait and defensive network connectivity and the modulatory effect of oxytocin on it

Full description

Individuals with high trait anxiety show stable anxiety proneness even in the absence of real threat, which could be a result of intrinsic hyper-connectivity in the defensive systems. In the present study, healthy subjects' trait anxiety levels will be assessed by the sub-trait inventory of the State-Trait Anxiety Inventory. Then two experiments using resting-state fMRI technique will be conducted to first map how hubs in the defensive systems organized in high anxious individuals in a stimuli-free situation (Experiment 1) and then we will examine the modulatory effect of the intranasal administration of oxytocin on functional connectivity in these independently defined defensive networks (Experiment 2).

Enrollment: 131 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy subjects without past or current psychiatric or neurological disorders

Exclusion criteria

• females should not be pregnant or during menstruation.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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131 participants in 4 patient groups, including a placebo group

high trait anxiety group

Experimental group

Description:

experiment 1: identified according to scores of the trait anxiety scale.

Treatment:

Behavioral: trait anxiety scale

low trait anxiety group

Experimental group

Description:

experiment 1: identified according to scores of the trait anxiety scale.

Treatment:

Behavioral: trait anxiety scale

oxytocin group

Experimental group

Description:

experiment 2: intranasal administration of oxytocin

Treatment:

Drug: Oxytocin

placebo control group

Placebo Comparator group

Description:

experiment 2: intranasal administration of placebo

Treatment:

Drug: Placebo