Trait Anxiety and Defensive Networks

U

University of Electronic Science and Technology of China

Status

Completed

Conditions

Healthy

Treatments

Drug: Oxytocin
Behavioral: trait anxiety scale
Drug: Placebo

Study type

Interventional

Funder types

Other

Identifiers

NCT02682888
UESTC-neuSCAN_20

Details and patient eligibility

About

to examine the association between trait and defensive network connectivity and the modulatory effect of oxytocin on it

Full description

Individuals with high trait anxiety show stable anxiety proneness even in the absence of real threat, which could be a result of intrinsic hyper-connectivity in the defensive systems. In the present study, healthy subjects' trait anxiety levels will be assessed by the sub-trait inventory of the State-Trait Anxiety Inventory. Then two experiments using resting-state fMRI technique will be conducted to first map how hubs in the defensive systems organized in high anxious individuals in a stimuli-free situation (Experiment 1) and then we will examine the modulatory effect of the intranasal administration of oxytocin on functional connectivity in these independently defined defensive networks (Experiment 2).

Enrollment

131 patients

Sex

All

Ages

18 to 35 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Healthy subjects without past or current psychiatric or neurological disorders

Exclusion criteria

  • females should not be pregnant or during menstruation.

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

131 participants in 4 patient groups, including a placebo group

high trait anxiety group
Experimental group
Description:
experiment 1: identified according to scores of the trait anxiety scale.
Treatment:
Behavioral: trait anxiety scale
low trait anxiety group
Experimental group
Description:
experiment 1: identified according to scores of the trait anxiety scale.
Treatment:
Behavioral: trait anxiety scale
oxytocin group
Experimental group
Description:
experiment 2: intranasal administration of oxytocin
Treatment:
Drug: Oxytocin
placebo control group
Placebo Comparator group
Description:
experiment 2: intranasal administration of placebo
Treatment:
Drug: Placebo

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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