Trajectories and Mechanisms of Recovery From Malaria: An Observational Study (SCRIPT)

Imperial College London

Status: Active, not recruiting

Conditions: Malaria

Treatments: Other: Symptomatic malaria

Study type: Observational

Funder types: Other

Identifiers

NCT05149157

21SM7226

Details and patient eligibility

About

This observational research study aims to answer the question: 'Which aspects of human biology play an important role in recovery from symptomatic malaria?'

In particular, the researchers aim to identify human genes for which the level of gene activity reflects the patient's overall rate of recovery. The researchers believe this approach may reveal new targets for adjunctive therapies.

The researchers aim to recruit 240 people, of all ages, who have been diagnosed with symptomatic malaria at selected hospitals in London. Blood samples, urine samples, and clinical information will be collected over the 14 days following malaria diagnosis.

Enrollment: 240 estimated patients

Sex: All

Ages: 8+ days old

Volunteers: No Healthy Volunteers

Inclusion criteria

Patients of any age with symptomatic malaria confirmed by asexual stage parasitaemia (of any Plasmodium species) on blood film.

Exclusion criteria

Patients with asymptomatic malaria; Patients with congenital malaria; Patients with Plasmodium gametocytaemia only; Patients with known HIV; Patients who have received antimalarial treatment for symptomatic malaria in the 28 days prior to hospital presentation; Patients who explicitly deny consent.