Tranexamic Acid in Hip Fracture Surgery

Spectrum Health Hospitals

Status: Completed

Conditions: Hip Fracture

Study type: Observational

Funder types: Other

Identifiers

NCT02736383

2016-060

Details and patient eligibility

About

To determine if TXA utilization is effective at reducing transfusion rates in elderly patients undergoing surgery for treatment of a hip fractures.

Enrollment: 142 patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Acute, isolated, unilateral femoral neck, intertrochanteric, and per trochanteric hip fractures confirmed by anteroposterior/lateral hip radiographs, computed tomography, or magnetic resonance imaging.
• Age 65 and older
• Low energy mechanism of injury
• Hip fracture fixation performed within 48 hours
• English speaking
• Anticipated medical optimization for operative fixation
• No other major trauma

Exclusion criteria

• Retained hardware around the affected hip
• Infection around the affected hip
• Transfer patients with a length of stay > 24 hours at the transferring hospital
• Diagnosis of deficient natural anticoagulation
• Known congenital thrombophilia (Deficiency of Protein C, S, Antithrombin)
• Known allergy to TXA
• Patients undergoing percutaneous pinning of the hip fracture

Trial design

142 participants in 2 patient groups

Tranexamic Acid

Description:

Patients that receive 2 gm TXA during surgery

No Tranexamic Acid

Description:

Patients that receive no TXA during surgery