Tranexamic Acid in Preventing Postpartum Hemorrhage in High Risk Pregnancies During Elective Cesarean Section

Mansoura University

Status and phase: Completed; Phase 3; Phase 2

Conditions: Postpartum Hemorrhage

Treatments: Drug: Tranexamic Acid

Study type: Interventional

Funder types: Other

Identifiers

NCT03351686

MansuraU

Details and patient eligibility

About

postpartum hemorrhage (PPT) represents one of the major causes of maternal mortality . Tranexamic acid is used in many studies in management of PPH in combination with ecobolics. this study aims to evaluate the possible value of the use of tranexamic acid in prevention of postpartum hemorrhage .

Enrollment: 140 patients

Sex: Female

Ages: 20 to 42 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Gestational age of 28 weeks or more.
• Chronic Hypertension.
• Preeclapmsia -Eclampsia.
• Multiple pregnancy.
• Uterine Liomyomas.
• Polyhydraminos.
• Fetal macrosomia.
• Associated Thrombocytopenia
• History of postpartum hemorrhage.

Exclusion criteria

• Patients with rheumatic heart disease.
• Patients with history Cardiac Valve Replacement.
• Current or past history of DVT.
• Women on any anticoagulant therapy.
• Sensitivity to tranexamic acid
• Pregnancies with any abnormally implanted or located placenta.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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140 participants in 2 patient groups

tranexamic acid group

Experimental group

Treatment:

Drug: Tranexamic Acid

non tranexamic (control) group

No Intervention group