Tranexamic Acid : Nebulization vs IV Route for Hemoptysis

University of Health Sciences Lahore

Status and phase: Completed; Phase 3; Phase 2

Conditions: NEBULIZATION; Tranexamic Acid; Hemoptysis

Treatments: Drug: Tranexamic Acid (TXA)

Study type: Interventional

Funder types: Other

Identifiers

NCT07212452

#NTranexamic#

Details and patient eligibility

About

This study compares the effect of tranexamic acid on hemoptysis when given through the conventional IV route and Through nebulization.

Full description

The investigators are conducting a randomized controlled trial for the comparison of routes through which tranexamic acid can be given to control hemoptysis. The study participants will be divided into 2 groups randomly and 1 group will be assigned to use IV route while other will be assigned the nebulization route and the result variables include the time taken for complete control of hemoptysis and recurrence time. Another variable is the reduction in amout of blood in sputum after each intervention.

Enrollment: 172 patients

Sex: All

Ages: 12 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients with mild to moderate hemoptysis < 600ml/ 24 hours of age 12 to 80 years and both genders.
2. Patients with hemoptysis due to infective pathology.
3. Patients with hemoptysis due to malignant pathology.

Exclusion criteria

1. Patients on antiplatelet therapy or aspirin
2. Hemoptysis after penetrating lung injury e.g. firearm injury
3. Patients with history of asthma

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

172 participants in 2 patient groups

Group receiving tranexamic acid via IV route

Active Comparator group

Description:

Tranexamic acid has been used conventionally for hemoptysis via IV route

Treatment:

Drug: Tranexamic Acid (TXA)

The Group receiving tranexamic acid via nebulization

Experimental group

Description:

Tranexamic acid when given through nebulization can be more effective than IV route in controlling hemoptysis

Treatment:

Drug: Tranexamic Acid (TXA)