Tranexamic Acid Versus Adrenaline for Controlling Iatrogenic Endobronchial Bleeding (TAVA)

Clinical Hospital Centre Zagreb

Status

Completed

Conditions

Hemoptysis

Bleeding

Treatments

Drug: Tranexamic acid

Drug: Adrenaline

Study type

Interventional

Funder types

Other

Identifiers

NCT04771923

8.1-21/20-2 02/21AG;

Details and patient eligibility

About

Endobronchial bleeding is a relatively common complication of diagnostic bronchoscopy. Both tranexamic acid and adrenaline are used topically for the control of endobronchial bleeding. The aim of this study is to compare the efficacy of tranexamic acid with adrenaline in controlling iatrogenic endobronchial bleeding after diagnostic bronchoscopy.

Enrollment

130 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

patients with endobronchial bleeding during diagnostic bronchoscopy that was not successfully controlled with cold (4°C) normal saline (3 aliquots of 5ml during 60sec)

Exclusion criteria

Any patient with a contraindication for diagnostic flexible bronchoscopy
Coagulopathy (PV INR >1.3)
Thrombocytopenia (<50x10^9) or anemia (hgb <80 g/L)
Direct oral anticoagulant, low molecular weight heparin or antiplatelet drug therapy
Thrombophilia, history of pulmonary embolism or deep vein thrombosis
Contraindication for endobronchial application of adrenaline
Coronary heart disease, cerebrovascular disease, history of tachyarrhythmia
Uncontrolled pulmonary hypertension
Cardiovascular decompensation
Severe hypoxia (PaO2 <60mmHg, SaO2 <90% with an FiO2 >=60%)