Trans-foraminal Lumbar Epidural Injection of Dexmedetomidine Against Magnesium Sulfate When Combined With Dexamethasone in Uni-lateral Lower Limb Radicular Pain. Multi-centeric Comparative Study

Minia University

Status: Completed

Conditions: Chronic Pain

Treatments: Drug: epidural transforaminal injection of magnesuim sulfate; Drug: transforaminal epidural injection of dexamethasone; Drug: epidural transforaminal injection of dexmedtemodine

Study type: Interventional

Funder types: Other

Identifiers

NCT05271721

R/219

Details and patient eligibility

About

Transforaminal injection of chronic radicular lower limb injection by either dexmedetomdine or magnesuim sulfate

Enrollment: 90 patients

Sex: All

Ages: 25 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age group. 25-75ys old
• Both sex.
• Lumber disc protrusion at one or two segments on MRI.
• Chronic lumbar radiculer pain for more than 6 weeks refractory to
• medical treatment for at least 4 weeks. .
• Positve leg rising test at 30-70 degrees.

Exclusion criteria

• Diabetic candidates ( type Ior II).
• Patient refusal.
• MRI with disc sequestration.
• Neurological examination revealed foot drop, neuropathic ulcers
• Myelopathic or scoliotic patients, .
• Coagulopathic patients ( cirrhotic patients, on anti-coagulation )

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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90 participants in 3 patient groups

control group

Other group

Description:

Dexamethasone 4 mg (1ml) plus 40 mg ( 2ml) lidocaine 2% plus 1ml sterile saline

Treatment:

Drug: transforaminal epidural injection of dexamethasone

Magnesuim group

Active Comparator group

Description:

. 200 mg Mg sulfate (1ml) plus 4 mg dexamethasone(1ml) plus 40mg lidocaine 2% (2ml)

Treatment:

Drug: epidural transforaminal injection of magnesuim sulfate

Dexmedetomidine group

Active Comparator group

Description:

Dexmedetmodine 50mic (0.5ml) ,4 mg dexamethasone (1ml), 40 mg lidocaine 2% (2ml) added to 4ml total volume with sterile saline .

Treatment:

Drug: epidural transforaminal injection of dexmedtemodine