Transbronchial Needle Aspiration in the Diagnosis of Peripheral Pulmonary Malignancy

Maggiore Bellaria Hospital, Bologna

Status: Completed

Conditions: Pulmonary Mass; Pulmonary Nodule

Treatments: Procedure: TBNA + transbronchial lung biopsy + bronchial washing

Study type: Observational

Funder types: Other

Identifiers

NCT00917137

02-Trisolini

Details and patient eligibility

About

The main purposes of this study are to assess the performance characteristics of transbronchial needle aspiration (TBNA) in the diagnosis of peripheral pulmonary lesions, and to identify the predictor variables of a positive aspirate.

Full description

In a recent systematic literature review (Rivera PM, Mehta AC; Chest 2007; 132: 1318-1488) TBNA showed the highest sensitivity in the diagnostic bronchoscopic approach to peripheral pulmonary lesions, as compared to the other available sampling techniques (transbronchial biopsy, brushing, washings). However, the Authors conclude that the data regarding TBNA in this setting deserve cautious interpretation because of the limited number of studies and the large differences in sample size). We designed the present study to assess the performance characteristics of TBNA, alone and in comparison with those of transbronchial biopsy, in the diagnosis of peripheral pulmonary lesions.

Enrollment: 200 estimated patients

Sex: All

Ages: 18 to 76 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18 years and older
• Pulmonary nodule (< 3 cm) or mass (> 3 cm) at computed tomography

Exclusion criteria

• Refusal to sign informed consent
• Uncontrolled coagulopathy
• Pregnancy

Trial design

200 participants in 1 patient group

Peripheral pulmonary lesions

Treatment:

Procedure: TBNA + transbronchial lung biopsy + bronchial washing