Transciptomic Modification Induced by miRNAs in Endometrial Fluid (miRNA_EF)

Stanford University

Status: Completed

Conditions: MicroRNA in Endometrial Fluid

Treatments: Procedure: Endometrial fluid aspiration

Study type: Interventional

Funder types: Other

Identifiers

NCT02554539

34225

Details and patient eligibility

About

The purpose of this study is to understand the mechanism of communication between the uterine environment and the preimplantation human embryo. The investigators are interested in understanding how the in-utero environment during the window of implantation is different in normal weight and overweight/obese women and how this may impact the programming of the developing embryo.

Enrollment: 10 patients

Sex: Female

Ages: 21 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Meet the WHO criteria for normal weight (BMI < 25) and overweight/obese (BMI > 25)
• Age 21-45

Exclusion criteria

• Age < 21 or > 45
• Women with history of hysterectomy

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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10 participants in 2 patient groups

Obese

Experimental group

Description:

Women, aged 21-45 with BMI \>30

Treatment:

Procedure: Endometrial fluid aspiration

Normal weight

Experimental group

Description:

Women, aged 21-45 with BMI \< 25

Treatment:

Procedure: Endometrial fluid aspiration