Transcranial Direct-Current Stimulation in Childhood Dystonia

University of Southern California

Status and phase: Unknown; Phase 2

Conditions: Childhood Onset Dystonias

Treatments: Device: sham TDCS (Transcranial Direct-current Stimulation); Device: TDCS (Transcranial Direct-current Stimulation)

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT01460771

TDCS2011

Details and patient eligibility

About

The investigators hypothesize that transcranial direct current stimulation over the motor cortex will reduce muscle overflow and improve hand function in children with primary or secondary dystonia.

Enrollment: 100 estimated patients

Sex: All

Ages: 4 to 21 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• dystonia affecting one or both hands
• age 4 to 21 years

Exclusion criteria

• metal implants in the head
• inability to cooperate with instructions

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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100 participants in 2 patient groups

Treatment

Experimental group

Description:

Active Transcranial Direct Current Stimulation (TDCS) at 1mA or highest tolerated current

Treatment:

Device: TDCS (Transcranial Direct-current Stimulation)

sham

Sham Comparator group

Description:

inactive Transcranial Direct current stimulation (TDCS) at 0mA

Treatment:

Device: sham TDCS (Transcranial Direct-current Stimulation)