Transcranial Direct Current Stimulation in Post-stroke Fatigue (TIPS)

University College London (UCL)

Status: Completed

Conditions: Stroke; Fatigue

Treatments: Device: Anodal tDCS; Device: sham tDCS

Study type: Interventional

Funder types: Other

Identifiers

NCT04634864

195246

Details and patient eligibility

About

This is a double-blind, sham-controlled, anodal tDCS study to understand the effect of increasing motor cortex excitability on post-stroke fatigue.

Enrollment: 33 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Diagnosed with stroke at least 3 months post-stroke

Exclusion criteria

Other neurological conditions on Anti-depressants severe motor impairment (affected hand grip <60% unaffected hand) severe cognitive impairment (unable to follow instructions, or give informed consent) scored >11 in the depression sub-section of HADS questionnaire contraindications for TMS or tES

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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33 participants in 2 patient groups

Anodal tDCS

Active Comparator group

Description:

40 minutes of 2mA intensity direct current stimulation

Treatment:

Device: Anodal tDCS

sham tDCS

Sham Comparator group

Description:

40 minutes of 0mA intensity. the session starts with a ramp up to 2mA, but machine is switched off after 2 minutes of stimulation.

Treatment:

Device: sham tDCS