Transcranial Direct Current Stimulation of the Primary Motor Cortex to Treat Levodopa-induced Dyskinesias

Institute of Hospitalization and Scientific Care (IRCCS)

Status: Enrolling

Conditions: Parkinson Disease

Treatments: Device: Transcranial direct current stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT05752240

3944

Details and patient eligibility

About

The main objective of the study is to evaluate the efficacy of 10 sessions of transcranial direct current stimulation of the primary motor cortex to reduce levodopa-induced dyskinesia

Enrollment: 32 estimated patients

Sex: All

Ages: 30 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with diagnosis of idiopathic Parkinson's disease according to Movement Disorder Society (MDS) criteria and levodopa-induced dyskinesia;
• age between 30 and 80 years;
• ongoing therapy with levodopa;
• fulfillment of requirements for the application of transcranial magnetic stimulation (TMS), assessed by completion of the TMS screening questionnaire.

Exclusion criteria

• patients unable to give informed consent;
• cognitive impairment (MMSE ≤ 24);
• history of epilepsy;
• pregnant women.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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32 participants in 2 patient groups

Active stimulation

Experimental group

Description:

Ten sessions of cathodic transcranial direct current stimulation over primary motor cortex

Treatment:

Device: Transcranial direct current stimulation

Sham stimulation

Sham Comparator group

Description:

Ten sessions of sham stimulation over primary motor cortex

Treatment:

Device: Transcranial direct current stimulation