Transcranial Direct Current Stimulation (tDCS) As A Treatment For Cigarette Craving and Cognitive Deficits in Schizophrenic (TDCSSCHIZ)

Nathan Kline Institute for Psychiatric Research

Status: Completed

Conditions: Cigarette Smoking; Schizophrenia; Cognition

Treatments: Device: tDCS

Study type: Interventional

Funder types: Other

Identifiers

NCT02128919

309320

Details and patient eligibility

About

This is a study of the effects of tDCS on smoking, craving for cigarettes, cognition, and psychiatric symptoms in schizophrenic patients who are current smokers or have a history of regular cigarette smoking. It assesses smoking with CO monitoring, nicotine and nicotine levels, and craving with QSU scale and response to craving slides. Cognition is measured by MCCB, symptoms are measured by PANSS and hallucination scale.

This is a double-blind sham-controlled study with active tDCS 2ma or 20 minutes over 5 days, and sham tDCS for 40 seconds on each sham occasion.

Enrollment: 33 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of schizophrenia spectrum disorder History of cigarette smoking

Exclusion criteria

• Seizure disorder or current treated neurological illness Current Acute exacerbation of psychotic state

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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33 participants in 2 patient groups

Active tDCS

Experimental group

Description:

tDCS 2 ma for 20 minutes with anode at DLPFC once a day for 5 days

Treatment:

Device: tDCS

Sham tDCS

Sham Comparator group

Description:

tDCS 2 ma for 40 seconds with anode at DLPFC for 5 days

Treatment:

Device: tDCS