Transcranial Direct Current Stimulation to Treat Major Depressive Disorder

University of Sao Paulo

Status and phase: Completed; Phase 3; Phase 2

Conditions: Major Depressive Disorder

Treatments: Procedure: transcranial direct current stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT01149889

USP-HU-002

Details and patient eligibility

About

The investigators purpose is to offer active Transcranial Direct Current Stimulation (tDCS) in patients of the investigators previous study who received either placebo or sertraline and have not responded.

Enrollment: 60 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Patients from a previous study (ID:USP-HU-001) who:

• received sertraline and did not respond.
• received placebo and did not respond.

Exclusion criteria

Patients from a previous study who:

• received active tDCS.
• responded.

Trial design

60 participants in 1 patient group

active stimulation

Experimental group

Description:

In active stimulation, the anode is placed over the left dorsolateral prefrontal cortex and the cathode is placed over the right prefrontal cortex. They are located five centimeters ventrally of the primary motor area, which are located five centimeters laterally of the central point of the scalp (which is located on the intersection of the sagittal and median curves). The device will deliver a charge of 2mA for 30 minutes.

Treatment:

Procedure: transcranial direct current stimulation